Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women.

ABSTRACT:

Background

Prospective studies consistently link low magnesium intake to higher type 2 diabetes (T2D) risk.

Objective

We examined the association of common genetic variants [single nucleotide polymorphisms (SNPs)] in genes related to magnesium homeostasis with T2D risk and potential interactions with magnesium intake.

Methods

Using the Women's Health Initiative-SNP Health Association Resource (WHI-SHARe) study, we identified 17 magnesium-related ion channel genes (583 SNPs) and examined their associations with T2D risk in 7287 African-American (AA; n = 1949 T2D cases) and 3285 Hispanic-American (HA; n = 611 T2D cases) postmenopausal women. We performed both single- and multiple-locus haplotype analyses.

Results

Among AA women, carriers of each additional copy o

SUBMITTER: Chan KH 

PROVIDER: S-EPMC4336527 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature