Endogenous human milk peptide release is greater after preterm birth than term birth.

ABSTRACT:

Background

Hundreds of naturally occurring milk peptides are present in term human milk. Preterm milk is produced before complete maturation of the mammary gland, which could change milk synthesis and secretion processes within the mammary gland, leading to differences in protein expression and enzymatic activity, thereby resulting in an altered peptide profile.

Objective

This study examined differences in peptides present between milk from women delivering at term and women delivering prematurely.

Methods

Nano-LC tandem mass spectrometry was employed to identify naturally occurring peptides and compare their abundances between term and preterm human milk samples at multiple time points over lactation. Term milk samples were collected from 8 mothers and preterm milk w

SUBMITTER: Dallas DC 

PROVIDER: S-EPMC4336528 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature