Do physical activity, smoking, drinking, or depression modify transitions from cognitive impairment to functional disability?

ABSTRACT:

Background

Individual-level modifiers can delay onset of limitations in basic activities of daily living (ADLs) among cognitively impaired individuals. We assessed whether these modifiers also delayed onset of limitations in instrumental ADLs (IADLs) among individuals at elevated dementia risk.

Objectives

To determine whether modifiable individual-level factors delay incident IADL limitations among adults stratified by dementia risk.

Methods

Health and Retirement Study participants aged 65+ without activity limitations in 1998 or 2000 (n = 5,219) were interviewed biennially through 2010. Dementia probability, categorized in quartiles, was used to predict incident IADL limitations with Poisson regression. We estimated relative (risk ratio) and absolute (number of limit

SUBMITTER: Rist PM 

PROVIDER: S-EPMC4336575 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature