Adverse vascular risk is related to cognitive decline in older adults.

ABSTRACT:

Background

Cardiovascular disease (CVD) and related risk factors are associated with Alzheimer's disease (AD). This association is less well-defined in normal cognition (NC) or prodromal AD (mild cognitive impairment, MCI).

Objective

Cross-sectionally and longitudinally relate a vascular risk index to cognitive outcomes among elders free of clinical dementia.

Methods

3,117 MCI (74 ± 8 years, 56% female) and 6,603 NC participants (72 ± 8 years, 68% female) were drawn from the National Alzheimer's Coordinating Center. A composite measure of vascular risk was defined using the Framingham Stroke Risk Profile (FSRP) score (i.e., age, systolic blood pressure, anti-hypertensive medication, diabetes, cigarette smoking, CVD history, atrial fibrillation). Ordinary linear regres

SUBMITTER: Jefferson AL 

PROVIDER: S-EPMC4336578 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature