Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.

ABSTRACT:

Background & aims

Mice exposed to the hepatocellular carcinogen diethylnitrosamine at 2 weeks of age have a high risk of developing primary liver tumors later in life. Previous studies have demonstrated that diethylnitrosamine-treated mice have increased tumor burden when fed an obesigenic "Western" diet rich in lard fat and sugar. However, the role of dietary fats vs. sugars in the promotion of liver cancer is poorly understood. The aim of this study was to determine how altering dietary fats vs. sugars affects tumor burden in the diethylnitrosamine model.

Methods

C57BL/6N mice were treated with diethylnitrosamine at 2 weeks of age and, from 6 to 32 weeks of age, fed one of five diets that differed in fat and sugar content, including normal chow, ketogenic, and Western diet

SUBMITTER: Healy ME 

PROVIDER: S-EPMC4336610 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature