A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging.

ABSTRACT:

Purpose

A novel application of two-dimensional (2D) spatially selective radiofrequency (2DRF) excitation pulses in hyperpolarized 13C imaging is proposed for monitoring the bolus injection with highly efficient sampling of the initially polarized substrate, thus leaving more polarization available for detection of the subsequently generated metabolic products.

Methods

A 2DRF pulse was designed with a spiral trajectory and conventional clinical gradient performance. To demonstrate the ability of our 2DRF bolus tracking pulse sequence, hyperpolarized [1-(13)ruvate in vivo imaging experiments were performed in normal rats, with a comparison to 1DRF excitation pulses.

Results

Our designed 2DRF pulse was able to rapidly and efficiently monitor the injected bolus dynamics i

SUBMITTER: Tang S 

PROVIDER: S-EPMC4336852 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature