The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database.

ABSTRACT:

Purpose

Previous observational studies have inconsistently associated early hyperoxia with worse outcomes after cardiac arrest, and have methodological limitations. We tested this association using a high-resolution database controlling for multiple disease-specific markers of severity of illness and care processes.

Methods

This was a retrospective analysis of a single-center, prospective registry of consecutive cardiac arrest patients. We included patients who survived and were mechanically ventilated ≥24 h after arrest. Our main exposure was arterial oxygen tension (PaO2), which we categorized hourly for 24 h as severe hyperoxia (>300 mmHg), moderate or probable hyperoxia (101-299 mmHg), normoxia (60-100 mmHg) or hypoxia (<60 mmHg). We controlled for Utstein-style covariat

SUBMITTER: Elmer J 

PROVIDER: S-EPMC4337386 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature