Homologs of the Acinetobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems.

ABSTRACT:

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Multidrug efflux systems are a major cause of resistance to antimicrobials in bacteria, including those pathogenic to humans, animals, and plants. These proteins are ubiquitous in these pathogens, and five families of bacterial multidrug efflux systems have been identified to date. By using transcriptomic and biochemical analyses, we recently identified the novel AceI (Acinetobacter chlorhexidine efflux) protein from Acinetobacter baumannii that conferred resistance to the biocide chlorhexidine, via an active efflux mechanism. Proteins homologous to AceI are encoded in the genomes of many other bacterial species and are particularly prominent within proteobacterial lineages. In this study, we expressed 23 homologs of AceI and examined their resistance and/or transport pr

SUBMITTER: Hassan KA 

PROVIDER: S-EPMC4337561 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature