MiR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6.

ABSTRACT: miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that post-transcriptional mechanisms restrict miR-128 accumulation to post-mitotic neurons during mouse corticogenesis and in adult stem cell niches. Whereas premature miR-128 expression in progenitors for upper layer neurons leads to impaired neuronal migration and inappropriate branching, sponge-mediated inhibition results in overmigration. Within the upper layers, premature miR-128 expression reduces the complexity of dendritic arborization, associated with altered electrophysiological properties. We show that Phf6, a gene mutated in the cognitive disorder Börjeson-Forssman-Lehmann syndrome, is an impo

SUBMITTER: Franzoni E 

PROVIDER: S-EPMC4337614 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature