Differential prefrontal and subcortical circuitry engagement during encoding of semantically related words in patients with late-life depression.

ABSTRACT:

Objective

Verbal memory difficulties are common among individuals with late-life depression (LLD), though there is limited knowledge about disruptions to underlying cerebral circuitry. The purpose of this study is to examine aberrations to cerebral networks implicated in encoding novel verbal semantic material among older adults with LLD.

Methods

Twenty-four older adults with early-onset LLD and 23 non-depressed comparisons participated in the study. Participants completed a word list-learning task while undergoing functional magnetic resonance imaging.

Results

In the context of equivalent recall and recognition of words following scanning and similar hippocampal volumes, patients with LLD exhibited less activation in structures known to be relevant for new learning a

SUBMITTER: Weisenbach SL 

PROVIDER: S-EPMC4337801 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature