Do environmental factors modify the genetic risk of prostate cancer?

ABSTRACT:

Background

Many SNPs influence prostate cancer risk. To what extent genetic risk can be reduced by environmental factors is unknown.

Methods

We evaluated effect modification by environmental factors of the association between susceptibility SNPs and prostate cancer in 1,230 incident prostate cancer cases and 1,361 controls, all white and similar ages, nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Trial. Genetic risk scores were calculated as number of risk alleles for 20 validated SNPs. We estimated the association between higher genetic risk (≥12 SNPs) and prostate cancer within environmental factor strata and tested for interaction.

Results

Men with ≥12 risk alleles had 1.98, 2.04, and 1.91 times the odds of total, advanced, and nonadvanced pro

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4337874 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature