Theoretical and experimental evaluation of multi-band EPI for high-resolution whole brain pCASL Imaging.

ABSTRACT: Multi-band echo planar imaging (MB-EPI), a new approach to increase data acquisition efficiency and/or temporal resolution, has the potential to overcome critical limitations of standard acquisition strategies for obtaining high-resolution whole brain perfusion imaging using arterial spin labeling (ASL). However, the use of MB also introduces confounding effects, such as spatially varying amplified thermal noise and leakage contamination, which have not been evaluated to date as to their effect on cerebral blood flow (CBF) estimation. In this study, both the potential benefits and confounding effects of MB-EPI were systematically evaluated through both simulation and experimentally using a pseudo-continuous arterial spin labeling (pCASL) strategy. These studies revealed that the amplified

SUBMITTER: Li X 

PROVIDER: S-EPMC4337884 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature