Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.

ABSTRACT:

Importance

We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), polygenic scores, and epistatic analyses. Of particular importance was the relative contribution of the polygenic score vs epistasis in variation explained.

Objectives

To (1) assess the association between SNPs in ZNF804A and the ZNF804A polygenic score with measures of cognition in cases with psychosis and (2) assess whether epistasis within the ZNF804A pathway could explain additional variation above and beyond that explained by the polygenic score.

Design, setting, and participants

Patients with psychosis (n = 424) were assessed in areas of cognitive

SUBMITTER: Nicodemus KK 

PROVIDER: S-EPMC4337973 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature