Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology.

ABSTRACT:

Rationale

Myocardial infarction is a leading cause of death in developed nations, and there remains a need for cardiac therapeutic systems that mitigate tissue damage. Cardiac progenitor cells (CPCs) and other stem cell types are attractive candidates for treatment of myocardial infarction; however, the benefit of these cells may be as a result of paracrine effects.

Objective

We tested the hypothesis that CPCs secrete proregenerative exosomes in response to hypoxic conditions.

Methods and results

The angiogenic and antifibrotic potential of secreted exosomes on cardiac endothelial cells and cardiac fibroblasts were assessed. We found that CPC exosomes secreted in response to hypoxia enhanced tube formation of endothelial cells and decreased profibrotic gene expression

SUBMITTER: Gray WD 

PROVIDER: S-EPMC4338016 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature