Radiation therapy after radical prostatectomy for prostate cancer: evaluation of complications and influence of radiation timing on outcomes in a large, population-based cohort.

ABSTRACT:

Purpose

To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer.

Methods

Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate cancer patients diagnosed during 1995-2007 who had one or more adverse pathological features after prostatectomy. The final cohort of 6,137 eligible patients included men who received prostatectomy alone (n = 4,509) or with adjuvant (n = 894) or salvage (n = 734) radiation therapy. Primary outcomes were genitourinary, gastrointestinal, and erectile dysfunction events and survival after treatment(s).

Results

Radiation therapy after prostatectomy was associated with higher rates of gastrointestinal and genitourinary events,

SUBMITTER: Hegarty SE 

PROVIDER: S-EPMC4338148 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature