The risk of cancer in patients with congenital heart disease: a nationwide population-based cohort study in Taiwan.

ABSTRACT:

Background

The relationship between congenital heart disease (CHD) and malignancies has not been determined. This study aimed to explore the association of CHD with malignancies and examine the risk factors for the development of cancer after a diagnosis of CHD.

Patients and methods

This nationwide, population-based cohort study on cancer risk evaluated 31,961 patients with newly diagnosed CHD using the Taiwan National Health Insurance Research Database (NHIRD) between 1998 and 2006. The standardized incidence ratios (SIRs) for all and specific cancer types were analyzed, while the Cox proportional hazard model was used to evaluate risk factors of cancer occurrence.

Results

Among patients with newly diagnosed CHD regardless of ages, 187 (0.6%) subsequently developed c

SUBMITTER: Lee YS 

PROVIDER: S-EPMC4338195 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature