Organophosphate pesticide exposure, PON1, and neurodevelopment in school-age children from the CHAMACOS study.

ABSTRACT:

Introduction

Organophosphate (OP) pesticides remain widely used in agriculture. Previously, we reported that PON1 genotype was directly associated with neurodevelopment at age two, and that PON1 genotype may increase susceptibility to OP exposure.

Objectives

We examined the relationships of maternal and child PON1 genotype and enzyme activity levels and neurodevelopment at school age and examined their interaction with maternal dialkyl phosphate (DAP) metabolite levels to investigate differential susceptibility to OP-related neurotoxicity.

Methods

Participants were from the CHAMACOS longitudinal birth cohort of Latino families in an agricultural region of California. We measured DAP metabolites of OP pesticides in maternal and child urine samples, and analyzed PON1192

SUBMITTER: Eskenazi B 

PROVIDER: S-EPMC4338203 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature