Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.

ABSTRACT: Pathogenic strains of Vibrio cholerae are responsible for endemic and pandemic outbreaks of the disease cholera. The complete toxigenic mechanisms underlying virulence in Vibrio strains are poorly understood. The hypothesis of this work was that virulent versus non-virulent strains of V. cholerae harbor distinctive genomic elements that encode virulence. The purpose of this study was to elucidate genomic differences between the O1 serotypes and non-O1 V. cholerae PS15, a non-toxigenic strain, in order to identify novel genes potentially responsible for virulence. In this study, we compared the whole genome of the non-O1 PS15 strain to the whole genomes of toxigenic serotypes at the phylogenetic level, and found that the PS15 genome was distantly related to those

SUBMITTER: Mukherjee M 

PROVIDER: S-EPMC4338557 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature