Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?

ABSTRACT:

Background

Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy. In organ-specific amyloidoses, soluble protein oligomers are the primary cytotoxic species in the process of protein aggregation. While isolated atrial amyloidosis can develop with aging, the presence of preamyloid oligomers (PAOs) in atrial tissue has not been previously investigated.

Methods and results

Atrial samples were collected during elective cardiac surgery in patients without a history of atrial arrhythmias, congestive heart failure, cardiomyopathy, or amyloidosis. Immunohistochemistry was performed for PAOs using a conformation-specific antibody, as well as for candidate proteins identified previously in isolated atrial amyloidosis.

SUBMITTER: Sidorova TN 

PROVIDER: S-EPMC4338732 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature