Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins.

ABSTRACT: Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types. This work represents an initial attempt at investigating the potential for predicting linkages between known cancer-associated proteins with uncharacterized or hypothetical multidomain proteins, based primarily on circular permutation (CP) relationships. First, we propose an efficient algorithm for rapid identification of both exact and approximate CPs in multidomain proteins. Using the circular relations identified, we construct networks between multidomain proteins, based on which we perform functional annotation of multidomain proteins. We then extend the me

SUBMITTER: Adjeroh D 

PROVIDER: S-EPMC4338801 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature