Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock.

ABSTRACT:

Introduction

Platelet mitochondrial respiratory chain enzymes (that produce energy) are variably inhibited during human sepsis. Whether these changes occur even during other acute critical illness or are associated with impaired platelet aggregation and secretion (that consume energy) is not known. The aims of this study were firstly to compare platelet mitochondrial respiratory chain enzymes activity between patients with sepsis and those with cardiogenic shock, and secondly to study the relationship between platelet mitochondrial respiratory chain enzymes activity and platelet responsiveness to (exogenous) agonists in patients with sepsis.

Methods

This was a prospective, observational, case-control study. Platelets were isolated from venous blood of 16 patients with severe

SUBMITTER: Protti A 

PROVIDER: S-EPMC4338849 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature