Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction.

ABSTRACT:

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Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these diseases are not understood. To expand our knowledge of the neuroinflammatory response in prion diseases, we assessed the expression of key genes and proteins involved in the inflammatory response and signal transduction in mouse brain at various times after scrapie infection. In brains of scrapie-infected mice at pre- and postclinical stages, we identified 15 previously unreported differentially expressed genes related to inflammation or activation of the STAT signal transduction pathway. Levels for the majority of differentially expressed genes increased with time postinfection. In quantitative

SUBMITTER: Carroll JA 

PROVIDER: S-EPMC4338885 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature