Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

ABSTRACT:

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A unique HIV-host equilibrium exists in untreated HIV-2-infected individuals. This equilibrium is characterized by low to undetectable levels of viremia throughout the disease course, despite the establishment of disseminated HIV-2 reservoirs at levels comparable to those observed in untreated HIV-1 infection. Although the clinical spectrum is similar in the two infections, HIV-2 infection is associated with a much lower rate of CD4 T-cell decline and has a limited impact on the mortality of infected adults. Here we investigated HIV-2 infection of the human thymus, the primary organ for T-cell production. Human thymic tissue and suspensions of total or purified CD4 single-positive thymocytes were infected with HIV-2 or HIV-1 primary isolates using either CCR5 or CXCR4 co

SUBMITTER: Nunes-Cabaco H 

PROVIDER: S-EPMC4338895 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature