Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis.

ABSTRACT:

Objective

We investigated the determinants and clinical correlations of MRI-detected brain volume loss (BVL) among patients with relapsing-remitting multiple sclerosis from the phase 3 trials of fingolimod: FREEDOMS, FREEDOMS II, and TRANSFORMS.

Methods

Post hoc analyses were conducted in the intent-to-treat populations from each trial and in a combined dataset of 3,635 patients from the trials and their extensions. The relationship between brain volume changes and demographic, clinical, and MRI parameters was studied in pairwise correlations (Pearson) and in multiple regression models. The relative frequency of confirmed disability progression was evaluated in the combined dataset by strata of concurrent BVL at up to 4 years.

Results

Increasing age, disease duration,

SUBMITTER: Radue EW 

PROVIDER: S-EPMC4339126 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature