Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.

ABSTRACT:

Objective

The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures.

Methods

All participants were treated with a cranially implanted responsive neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically implanted electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed a 2-year primarily open-label safety study (n = 65) or a 2-year randomized blinded controlled safety and efficacy study (n = 191); 230 participants transitioned into an ongoing 7-year study to assess safety and efficacy.

Results

The average participant was 34 (±11.4) years old with epilepsy for 19.6 (±11.4) years. The median preimplant frequenc

SUBMITTER: Bergey GK 

PROVIDER: S-EPMC4339127 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature