Membrane-mediated interaction between strongly anisotropic protein scaffolds.

ABSTRACT: Specialized proteins serve as scaffolds sculpting strongly curved membranes of intracellular organelles. Effective membrane shaping requires segregation of these proteins into domains and is, therefore, critically dependent on the protein-protein interaction. Interactions mediated by membrane elastic deformations have been extensively analyzed within approximations of large inter-protein distances, small extents of the protein-mediated membrane bending and small deviations of the protein shapes from isotropic spherical segments. At the same time, important classes of the realistic membrane-shaping proteins have strongly elongated shapes with large and highly anisotropic curvature. Here we investigated, computationally, the membrane mediated interaction between proteins or protein oligomers

SUBMITTER: Schweitzer Y 

PROVIDER: S-EPMC4339200 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature