Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos.

ABSTRACT: DNA methylation undergoes dynamic changes during development and cell differentiation. Recent genome-wide studies discovered that tissue-specific differentially methylated regions (DMRs) often overlap tissue-specific distal cis-regulatory elements. However, developmental DNA methylation dynamics of the majority of the genomic CpGs outside gene promoters and CpG islands has not been extensively characterized. Here, we generate and compare comprehensive DNA methylome maps of zebrafish developing embryos. From these maps, we identify thousands of developmental stage-specific DMRs (dsDMRs) across zebrafish developmental stages. The dsDMRs contain evolutionarily conserved sequences, are associated with developmental genes and are marked with active enhancer histone posttranslational modificatio

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC4339225 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature