Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis.

ABSTRACT:

Rationale

A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial processes for muscle development and regeneration.

Objective

The objective of this study was to identify the role of the hedgehog transcription factor Gli3 in the cross-talk between angiogenesis and myogenesis in adults.

Methods and results

Using conditional knockout mice, we found that Gli3 deficiency in endothelial cells did not affect ischemic muscle repair, whereas in myocytes, Gli3 deficiency resulted in severely delayed ischemia-induced myogenesis. Moreover, angiogenesis was also significantly impaired i

SUBMITTER: Renault MA 

PROVIDER: S-EPMC4339272 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature