Genetic variation as a modifier of association between therapeutic exposure and subsequent malignant neoplasms in cancer survivors.

ABSTRACT: Subsequent malignant neoplasms (SMNs) are associated with significant morbidity and are a major cause of premature mortality among cancer survivors. Several large studies have demonstrated a strong association between the radiation and/or chemotherapy used to treat primary cancer and the risk of developing SMNs. However, for any given therapeutic exposure, the risk of developing an SMN varies between individuals. Genomic variation can potentially modify the association between therapeutic exposures and SMN risk and may explain the observed interindividual variability. In this review, the author provides a brief overview of the current knowledge regarding the role of genomic variation in the development of therapy-related SMNs and discusses the methodological challenges in undertaking an en

SUBMITTER: Bhatia S 

PROVIDER: S-EPMC4339370 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature