Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

ABSTRACT:

Background

The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from clonal evolution and the emergence of subclonal tumour populations in HGSOC was associated with the development of resistant disease.

Methods and findings

Evolutionary inference and phylogenetic quantification of heterogeneity was performed using the MEDICC algorithm on high-resolution whole genome copy number profiles and selected genome-wide sequencing of 135 spatially and temporally separated samples from 14 patients with HGSOC who received platinum-based chemotherapy. Samples were obtained from

SUBMITTER: Schwarz RF 

PROVIDER: S-EPMC4339382 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature