Practical guidance for conducting mediation analysis with multiple mediators using inverse odds ratio weighting.

ABSTRACT: Despite the recent flourishing of mediation analysis techniques, many modern approaches are difficult to implement or applicable to only a restricted range of regression models. This report provides practical guidance for implementing a new technique utilizing inverse odds ratio weighting (IORW) to estimate natural direct and indirect effects for mediation analyses. IORW takes advantage of the odds ratio's invariance property and condenses information on the odds ratio for the relationship between the exposure (treatment) and multiple mediators, conditional on covariates, by regressing exposure on mediators and covariates. The inverse of the covariate-adjusted exposure-mediator odds ratio association is used to weight the primary analytical regression of the outcome on treatment. The treat

SUBMITTER: Nguyen QC 

PROVIDER: S-EPMC4339385 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature