Genetic diversity of medically important and emerging Candida species causing invasive infection.

ABSTRACT:

Background

Genetic variation in the ribosomal DNA (rDNA) internal transcribed spacer (ITS) region has been studied among fungi. However, the numbers of ITS sequence polymorphisms in the various Candida species and their associations with sources of invasive fungal infections remain poorly investigated. Here, we characterized the intraspecific and interspecific ITS diversity of Candida spp. strains collected from patients with bloodstream or oroesophageal candidiasis.

Methods

We selected cultures of representative medically important species of Candida as well as some rare and emerging pathogens. Identification was performed by micromorphology and by biochemical testing using an ID32C system, as well as by the sequencing of rDNA ITS. The presence of intraspecific ITS polymorp

SUBMITTER: Merseguel KB 

PROVIDER: S-EPMC4339437 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature