The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study.

ABSTRACT:

Background

Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.

Objective

To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).

Methods

Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ± SD age = 74 ± 3 y; 67% female). The adjusted odds ratios (and

SUBMITTER: Shea MK 

PROVIDER: S-EPMC4339507 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature