The effect of donor diabetes history on graft failure and endothelial cell density 10 years after penetrating keratoplasty.

ABSTRACT:

Objective

To examine the long-term effect of donor diabetes history on graft failure and endothelial cell density (ECD) after penetrating keratoplasty (PK) in the Cornea Donor Study.

Design

Multicenter, prospective, double-masked, controlled clinical trial.

Participants

One thousand ninety subjects undergoing PK for a moderate risk condition, principally Fuchs' dystrophy or pseudophakic or aphakic corneal edema, were enrolled by 105 surgeons from 80 clinical sites in the United States.

Methods

Corneas from donors 12 to 75 years of age were assigned by 43 eye banks to participants without respect to recipient factors. Donor and recipient diabetes status was determined from existing medical records. Images of the central endothelium were obtained before surgery (

SUBMITTER: Lass JH 

PROVIDER: S-EPMC4339512 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature