Mechanisms of integral membrane protein insertion and folding.

ABSTRACT: The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to understand because they underlie virtually all physiological processes in cells including key metabolic pathways, such as the respiratory chain and the photosystems, as well as the transport of solutes and signals across membranes. Nearly all MPs require translocons--often referred to as protein-conducting channels--for proper insertion into their target membrane. Remarkable progress toward understanding the structure and functioning of translocons has been made during the past decade. Here, we review and assess this progress critically. All available evidence indicates that MPs are equilibrium structures that achieve their final structural states by folding along thermodynamically controlled pathw

SUBMITTER: Cymer F 

PROVIDER: S-EPMC4339636 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature