Association between circulating levels of sex steroid hormones and Barrett's esophagus in men: a case-control analysis.

ABSTRACT:

Background & aims

Esophageal adenocarcinoma is believed to result from the progression of gastroesophageal reflux disease to erosive esophagitis and re-epithelialization of the esophagus with a columnar cell population termed Barrett's esophagus (BE). Men develop BE and esophageal adenocarcinoma more frequently than women, yet little is known about the mechanisms of this difference. We assessed whether sex steroid hormones were associated with BE in a male population.

Methods

We analyzed data from the Barrett's Esophagus Early Detection Case Control Study, based at the Walter Reed National Military Medical Center. Blood samples were collected from 174 men with BE and 213 men without BE (controls, based on endoscopic analysis); 13 sex steroid hormones were measured by mass sp

SUBMITTER: Cook MB 

PROVIDER: S-EPMC4339666 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature