Predictive value of interferon-gamma release assays for postpartum active tuberculosis in HIV-1-infected women.

ABSTRACT:

Background

Data on the prognostic utility of interferon-gamma release assays (IGRAs) for active tuberculosis (TB) among human immunodeficiency virus 1 (HIV-1) infected individuals are limited.

Methods

Samples from a perinatal cohort of HIV-1-infected women in Kenya, obtained during pregnancy, were tested using T-SPOT®.TB IGRAs to detect Mycobacterium tuberculosis-specific interferon-gamma (IFN-γ) responses. IFN-γ (cut-off values of >0, ≥6 and ≥10 spot-forming cells [SFC]/well) and CD4 cell count (cut-off values of <250 and <350 cells/l) were evaluated to determine sensitivity and specificity using a time-dependent receiver operating characteristic curve and positive predictive value (PPV) using the Kaplan Meier method for future TB within 1 year postpartum.

Results

Of

SUBMITTER: Jonnalagadda SR 

PROVIDER: S-EPMC4339676 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature