2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.

ABSTRACT: A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.

SUBMITTER: Sayer JR 

PROVIDER: S-EPMC4339681 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature