Clinicopathological and prognostic significance of survivin expression in patients with oral squamous cell carcinoma: evidence from a meta-analysis.

ABSTRACT:

Background

Survivin has been proposed as a promising prognostic marker in oral squamous cell carcinoma (OSCC), but the published data on survivin expression in patients with this condition are controversial. To address this we performed a meta-analysis systematically to assess the clinicopathological and prognostic significance of survivin expression in OSCC.

Methods

We searched PubMed, Embase, Web of Science and Ovid databases for papers investigating the clinicopathological and prognostic significance of survivin expression in OSCC. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to determine the relevance of survivin.

Results

A total of 15 papers, including 1040 cases in which survivin expression was detected by immunohistoch

SUBMITTER: Xie S 

PROVIDER: S-EPMC4339736 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature