Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.

ABSTRACT:

Background

Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.

Methods

We pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Results

The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower propo

SUBMITTER: Toporcov TN 

PROVIDER: S-EPMC4339764 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature