Local and global ancestry inference and applications to genetic association analysis for admixed populations.

ABSTRACT: Genetic association studies in recently admixed populations offer exciting opportunities to identify novel variants underlying phenotypic diversity. At the same time, genetic heterogeneity resulting from population admixture has to be accounted for to ensure validity of association tests. The whole-genome sequence data and the genome-wide single-nucleotide polymorphism chip data for Mexican American individuals provided by Genetic Analysis Workshop 18 (GAW18) presents a unique opportunity to evaluate and compare methods for the statistical analysis of admixed genetic data. We summarize here the five contributions from the GAW18 working group on admixture mapping and adjusting for admixture. Although group members considered a variety of research topics, the general theme was inference and

SUBMITTER: Thornton TA 

PROVIDER: S-EPMC4339867 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature