Molecular basis of Rh blood group system in the Malaysian population.

ABSTRACT:

Background

Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians.

Aims

This study aims to characterize the Rh genes and frequency of the various RH genotypes among blood donors in National Blood Centre (NBC), Kuala Lumpur.

Materials and methods

A total of 1014 blood samples were obtained from blood donors from four different ethnic groups (360 Malays, 434 Chinese, 164 Indians and 56 others). Serological and molecular analysis of all 1014 blood samples were performed. An automated deoxyribonucleic acid sequencing analysis was performed.

Results

Rh phenotypes and RH genotypes showed heterogeneity and significant association with ethnicities. Dis

SUBMITTER: Musa RH 

PROVIDER: S-EPMC4339932 | biostudies-literature | 2015 Jan-Jun

REPOSITORIES: biostudies-literature