Roux-en Y gastric bypass surgery induces genome-wide promoter-specific changes in DNA methylation in whole blood of obese patients.

ABSTRACT:

Context

DNA methylation has been proposed to play a critical role in many cellular and biological processes.

Objective

To examine the influence of Roux-en-Y gastric bypass (RYGB) surgery on genome-wide promoter-specific DNA methylation in obese patients. Promoters are involved in the initiation and regulation of gene transcription.

Methods

Promoter-specific DNA methylation in whole blood was measured in 11 obese patients (presurgery BMI >35 kg/m(2), 4 females), both before and 6 months after RYGB surgery, as well as once only in a control group of 16 normal-weight men. In addition, body weight and fasting plasma glucose were measured after an overnight fast.

Results

The mean genome-wide distance between promoter-specific DNA methylation of obese patients at six

SUBMITTER: Nilsson EK 

PROVIDER: S-EPMC4340013 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature