The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

ABSTRACT:

Background

Clinical research characterizing the mechanisms responsible for sex-based outcome differences after injury remains conflicting. Currently lacking is an understanding of the early sex hormone milieu of the injured patient and the effects these early hormone differences have on clinical outcomes and the innate immune response following injury.

Methods

A prospective cohort study was performed over a 20-month period. Blunt injury patients requiring intensive care unit admission were enrolled. Samples were collected within 6 hours and at 24 hours after injury and were analyzed for total testosterone (TT) and estradiol concentrations. Outcomes of interest included multiple-organ failure (MOF; Marshall Multiple Organ Dysfunction Score [MODScore] > 5), nosocomial infectio

SUBMITTER: Zolin SJ 

PROVIDER: S-EPMC4340085 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature