Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction.

ABSTRACT:

Rationale

Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury.

Objective

We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might improve infarct size in ST-elevated myocardial infarction.

Methods and results

Patients undergoing primary percutaneous coronary intervention (n=80) were randomized to receive intracoronary (10 mL) sodium nitrite (1.8 μmol) or NaCl (placebo) before balloon inflation. The primary end point was infarct size assessed by measuring creatine kinase release. Secondary outcomes included infarct size assessed by troponin T release and by cardiac MRI on day 2. Baseline characteristics were s

SUBMITTER: Jones DA 

PROVIDER: S-EPMC4340586 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature