Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia.

ABSTRACT:

Purpose

Researchers studying the murine response to stress generally use mice housed under standard, nationally mandated conditions as controls. Few investigators are concerned whether basic physical aspects of mouse housing could be an additional source of stress, capable of influencing the subsequent impact of an experimentally applied stressor. We have recently become aware of the potential for housing conditions to impact important physiological and immunological properties in mice.

Materials and methods

Here we sought to determine whether housing mice at standard temperature (ST; 22 °C) vs. thermoneutral temperature (TT; 30 °C) influences baseline expression of heat shock proteins (HSPs) and their typical induction following a whole body heating.

Results

There we

SUBMITTER: Eng JW 

PROVIDER: S-EPMC4340593 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature