Small molecule Mcl-1 inhibitors for the treatment of cancer.

ABSTRACT: The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.

SUBMITTER: Belmar J 

PROVIDER: S-EPMC4340597 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature