Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system.

ABSTRACT: In the cardiovascular system, changes in oxidative balance can affect many aspects of cellular physiology through redox-signaling. Depending on the magnitude, fluctuations in the cell's production of reactive oxygen and nitrogen species can regulate normal metabolic processes, activate protective mechanisms, or be cytotoxic. Reactive oxygen and nitrogen species can have many effects including the posttranslational modification of proteins at critical cysteine thiols. A subset can act as redox-switches, which elicit functional effects in response to changes in oxidative state. Although the general concepts of redox-signaling have been established, the identity and function of many regulatory switches remains unclear. Characterizing the effects of individual modifications is the key to under

SUBMITTER: Chung HS 

PROVIDER: S-EPMC4340704 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature