Edge density imaging: mapping the anatomic embedding of the structural connectome within the white matter of the human brain.

ABSTRACT: The structural connectome has emerged as a powerful tool to characterize the network architecture of the human brain and shows great potential for generating important new biomarkers for neurologic and psychiatric disorders. The edges of the cerebral graph traverse white matter to interconnect cortical and subcortical nodes, although the anatomic embedding of these edges is generally overlooked in the literature. Mapping the paths of the connectome edges could elucidate the relative importance of individual white matter tracts to the overall network topology of the brain and also lead to a better understanding of the effect of regionally-specific white matter pathology on cognition and behavior. In this work, we introduce edge density imaging (EDI), which maps the number of network edges t

SUBMITTER: Owen JP 

PROVIDER: S-EPMC4340739 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature