The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis.

ABSTRACT:

Purpose

ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is anchored as transmembrane protein in the endoplasmic reticulum. Gasdermin B (GSDMB) is adjacent to ORMDL3 on chromosome 17q21.2 and belongs to the gasdermin-domain containing the protein family (GSDM family). Recent reports suggest that GSDMB and ORMDL3 are associated with asthma in several populations. However, genetic association studies that examined the association of GSDMB and ORMDL3 gene variants with asthma showed conflicting results. To assess whether combined evidence shows the association between GSDMB/ORMDL3 polymorphism and asthma.

Methods

A bibliographic search from MEDLINE identified 13 original articles using the search keywords 'GSDMB', 'ORMDL3', and 'asthma'. An updated litera

SUBMITTER: Zhao CN 

PROVIDER: S-EPMC4341339 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature